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A role for the regulation of cellular Ca²⁺ homeostasis in the dopaminergic control of prolactin secretion was investigated in rat anterior pituitary glands. Withdrawal of dopamine stimulated the uptake of ⁴⁵Ca²⁺ into hemipituitary tissue by 48% after 3 min. Radioisotope desaturation from tissue prelabelled with ⁴⁵Ca²⁺ was significantly retarded in the presence of dopamine. Withdrawal of dopamine rapidly stimulated ⁴⁵Ca²⁺ efflux from prelabelled tissue by 79% and was accompanied by a three- to fourfold rise in prolactin secretion. The ⁴⁵Ca²⁺ efflux response to dopamine withdrawal was reduced in tissue prelabelled in the presence of dopamine. Agonist displacement with metoclopramide mimicked the effect of dopamine withdrawal on ⁴⁵Ca²⁺ efflux and prolactin secretion.

These observations demonstrate that the stimulation of prolactin release by dopamine withdrawal is accompanied by a redistribution of cellular Ca²⁺ and support the hypothesis that dopamine inhibits secretion by decreasing Ca²⁺ influx in the mammotroph cell.

J. Endocr. (1986) 108, 423–429

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