HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Bassett, N. S. Articles by Gluckman, P. D. Search for Related Content PubMed Articles by Bassett, N. S. Articles by Gluckman, P. D.

The ontogenesis of the pulsatility of GH in the ovine fetus was determined by obtaining blood samples at 20-min intervals for 3-h periods from fetuses (n = 33) at various stages of development (76–147 days gestation), and in neonatal life (n = 19). A significant increase (P <0·01) in the GH mean, nadir and maximum, and pulse height was observed between the ages of 100 and 130–139 days of gestation. An analysis of the difference in the mean, maximum and nadir concentrations between 100 and 139 days of gestation revealed that males had higher GH levels than females (P <0·05).

There was a significant fall in plasma GH concentrations from 140 days of gestation to term, but before the onset of active labour. There was a more rapid fall in the circulating levels of fetal GH directly following birth. Immediately before birth fetal GH levels were still relatively high, but within 60 min of birth they had fallen by more than 80%.

It is suggested that these changes in the pulsatile pattern of GH release are a consequence of both maturational changes in the hypothalamic-pituitary unit and the effects of pregnancy-related factors on GH release. The sexually dimorphic nature of GH release in the adult is also observed in the sheep fetus during late gestation.

J. Endocr. (1986) 109, 307–312

This article has been cited by other articles:

				F. d. Zegher, I. Francois, m. van helvoirt, and g. van den berghe Small as Fetus and Short as Child: From Endogenous to Exogenous Growth Hormone J. Clin. Endocrinol. Metab., July 1, 1997; 82(7): 2021 - 2026. [Full Text] [PDF]