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Plasma GH, tri-iodothyronine (T₃), thyroxine (T₄) and liver 5'-monodeiodination (5'-D) activity were measured in 18-day-old chick embryos injected with thyrotrophin-releasing hormone (TRH) and human pancreatic growth hormone releasing factor (hpGRF). Injections of 0·1 and 1 µg TRH and 1·5 µg hpGRF increased the concentration of plasma GH while injection of 15 µg hpGRF had no effect. Concentrations of plasma T₃ were raised after injection of TRH or hpGRF. Injections of TRH but not of hpGRF raised the concentration of plasma T₄. The increases in concentration of plasma T₃ after injection of TRH or hpGRF were parallelled by increases in liver 5'-D activity. An injection of 0·25 µg T₄ significantly raised the concentration of T₄ in plasma but had no effect on plasma T₃ or liver 5'-D activity. It is concluded that the release of chicken GH by TRH or hpGRF is responsible for the observed increases in plasma concentration of T₃ and liver 5'-D activity.

J. Endocr. (1988) 118, 233–236

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