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In many male vertebrates, androgens stimulate, while progesterone inhibits, sexual behaviour. Testicular androgens also control sexual behaviour in males of the lizard Cnemidophorus inornatus. However, administration of progesterone will reinstate sexual behaviour in castrated animals. Increased doses of progesterone did not result in increased numbers of responders; at all doses tested approximately 36% (n = 45) of animals treated with progesterone responded as reliable courters. A high percentage (60–68%) of progesterone-sensitive individuals maintained their sensitivity over a period of months. A synthetic progestin 17,21-dimethyl-19-nor-4,9-pregnadiene-3,20-dione with low rates of metabolism and conversion, also stimulated sexual behaviour in castrated C. inornatus. Finally, the synthetic antiprogestin 11β-4-dimethylaminophenyl-17β-hydroxy-17-1-propinyl-4,9-oestradiene-3-one inhibited the stimulatory effects of progesterone on sexual behaviour but failed to inhibit the stimulatory effects of androgens. These findings indicate an unusual departure from the characteristic pattern of steroid sensitivities of neural centres controlling sexual behaviour.

J. Endocr. (1988) 119, 265–273

This article has been cited by other articles:

				D. Crews, J. Godwin, V. Hartman, M. Grammer, E. A. Prediger, and R. Sheppherd Intrahypothalamic Implantation of Progesterone in Castrated Male Whiptail Lizards (Cnemidophorus inornatus) Elicits Courtship and Copulatory Behavior and Affects Androgen Receptor- and Progesterone Receptor-mRNA Expression in the Brain J. Neurosci., November 15, 1996; 16(22): 7347 - 7352. [Abstract] [Full Text] [PDF]