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Cyclic AMP levels were measured in freshly isolated hepatocytes of the rainbow trout. Compared with basal values, the average levels were increased up to 60 times in a dose-dependent manner either by mammalian glucagon (concentration range 1 nmol– 1 µmol/l; dose giving half maximum response (EC₅₀) 0· 18 µmol/l) or by forskolin (concentration range 0·1–100 µmol/l; EC₅₀ about 10 µmol/l). These stimulatory effects were partially inhibited by fish or mammalian neurohypophysial hormones used at relatively high concentrations (1–5 µmol/l). It is suggested that these results are evidence for the presence of V₁-type receptors in fish hepatocytes. Together with previous results obtained with gills on the hormonal inhibition of adenylate cyclase activity, they suggest that teleost fish may possess only V₁-type receptors (or two V₁-related types), while the V₂ receptors have evolved (or have become functional) in higher vertebrates.

J. Endocr. (1988) 119, 439–445