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Two women, who had undergone bilateral ovariectomy and adrenalectomy for carcinomatosis secondary to primary growths of the breast, received 100 mg progesterone in arachis oil intramuscularly for 3 days. Estimations of pregnane-3():20()-diol, total 17-ketosteroids and dehydroisoandrosterone and its derivatives were made on 24 hr urine specimens collected for a control period, while the patients received progesterone, and for 3 days afterwards. Both patients excreted increased amounts of pregnane-3():20()-diol and one excreted increased amounts of 17-ketosteroids and dehydroisoandrosterone and its derivatives.