HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Amadieu-Farmakis, M. Articles by Barlet, J.-P. Search for Related Content PubMed Articles by Amadieu-Farmakis, M. Articles by Barlet, J.-P.

Plasma concentrations of atrial natriuretic peptide (ANP) were studied in eight adult non-pregnant cows and in two groups of six chronically catheterized bovine fetuses and their mothers in the eighth month of pregnancy. The first group of fetuses was used for studying the effect of an acute i.v. sodium load (240 mmol NaCl/fetus) on fetal ANP; the second group acted as controls. The mean basal ANP levels in the third-trimester bovine fetus were three to four times higher than maternal values (39·5 ± 5·5 and 9·4 ± 0·6 pmol/l respectively; P<0·01). Basal maternal plasma ANP levels were twice as high in pregnant cows in the third trimester of pregnancy than in non-pregnant cows (9·4 ± 0·6 and 4·3 ± 0·7 pmol/l respectively; P<0·05).

In response to an i.v. hypertonic saline injection, fetal plasma ANP levels increased significantly (P<0·01) to a maximum of 86·7± 17·6 pmol/l 10 min after the injection, and returned to baseline within 60 min after the treatment; during the 20 min following the i.v. sodium load, fetal plasma ANP correlated significantly with fetal plasma sodium concentrations (r 0·96; n=12) and with fetal plasma osmolality (r =0·94; n=12). No significant changes in maternal ANP values were observed in the two groups of animals.

These results suggest that ANP secretion is stimulated during pregnancy in cows, and that, in the bovine fetus, a hypertonic sodium load appears to be a potent stimulus for ANP release.

Journal of Endocrinology (1989) 121, 5–9

This article has been cited by other articles:

				P. L. Roubertoux, I. Le Roy, S. Tordjman, A. Cherfou, and D. Migliore-Samour Analysis of Quantitative Trait Loci for Behavioral Laterality in Mice Genetics, March 1, 2003; 163(3): 1023 - 1030. [Abstract] [Full Text] [PDF]