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Journal of Endocrinology (1989) 121, 75-79    DOI: 10.1677/joe.0.1210075
© 1989 Society for Endocrinology
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Vitamin A deficiency and tri-iodothyronine action at the cellular level in the rat

 P. Higueret, I. Pailler and H. Garcin

Young rats were given a diet with or without vitamin A for a period of 7 weeks. In rats on the vitamin A-deficient diet, the formation of tri-iodothyronine (T3) complexes with nuclear proteins was reduced, and Scatchard analysis showed a decreased capacity of nuclear T3 receptors. In these rats, a decrease in growth and a decrease in the activity of lipogenic enzymes (glucose-6-phosphate dehydrogenase, phosphogluconate dehydrogenase and L-malate dehydrogenase) occurred, which could be related to the decreased formation of T3–nuclear protein complexes.

Journal of Endocrinology (1989) 121, 75–79




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