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A heterologous inhibin radioimmunoassay method to measure inhibin in serum of male cynomolgus (Macaca fascicularis) and rhesus (Macaca mulatta) monkeys has been validated using a specific antibody against bovine 31 kDa inhibin and ¹²⁵I-labelled 31 kDa inhibin as tracer. A serum pool from male monkeys was used as standard. Serial dilutions of normal monkey serum showed parallel logit–log dose–response curves to purified porcine and bovine inhibin as well as to a female human serum pool. The intra-assay coefficient of variation was 4·2% (n=10) and the interassay coefficient of variation 5·1% (n=10). No loss of inhibin immunoactivity was noted after storage at 23 °C for 5 days or repeated thawing and freezing of the serum samples. Serum from castrated monkeys showed undetectable levels of inhibin. Treatment with a gonadotrophin-releasing hormone agonist for 15 weeks led to a marked suppression of peripheral serum inhibin to concentrations similar to those after hypophysectomy or pituitary stalk section.

Journal of Endocrinology (1989) 122, 477–483

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				T. M. Plant, V. Padmanabhan, S. Ramaswamy, D. S. McConnell, S. J. Winters, N. Groome, A. R. Midgley Jr., and A. S. McNeilly Circulating Concentrations of Dimeric Inhibin A and B in the Male Rhesus Monkey (Macaca mulatta) J. Clin. Endocrinol. Metab., August 1, 1997; 82(8): 2617 - 2621. [Abstract] [Full Text] [PDF]