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The importance of pulsatility in Endocrinology requires no emphasis; it is an ubiquitous mode of secretion reflecting fundamental principles about the organization of hormone release mechanisms. Pulsatility is clearly exhibited in the output of hormone from the anterior pituitary gland (for recent review see Robinson & Dyer, 1988) and this is particularly striking in the case of luteinizing hormone (LH). Today, two decades after the discovery of the pulsatile nature of LH secretion, an enormous literature details variations in the characteristics of gonadotrophin release with change in physiological state in many different species. For example, we know that dramatic changes in both the frequency and amplitude of LH episodes occur at puberty, during female sexual cycles, in seasonal breeders and in a range of pathological states. Despite this we are still surprisingly ignorant of the mechanisms which cause LH to be released as a discrete bolus.

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				F. Van Goor, D. Zivadinovic, A. J. Martinez-Fuentes, and S. S. Stojilkovic Dependence of Pituitary Hormone Secretion on the Pattern of Spontaneus Voltage-gated Calcium Influx. CELL TYPE-SPECIFIC ACTION POTENTIAL SECRETION COUPLING J. Biol. Chem., August 31, 2001; 276(36): 33840 - 33846. [Abstract] [Full Text] [PDF]