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The uptake of 3,5,3'-tri-iodothyronine (T₃) by human erythrocytes was shown to occur by two saturable processes. System I (Michaelis constant (K_m) 109 ± 40 (mean ± S.D.) nmol/l; maximal velocity (V_max) = 43 ± 16 pmol/min per 10⁹ cells) was observed over the range 1–50 nmol T₃/l whilst system II (K_m = 8·8 ± 8·0 pmol/l; V_max = 29 ± 6 fmol/min per 10⁹ cells) was observed over the range 1–500 pmol T₃/l. At low concentrations (1–500 pmol/l) uptake processes equivalent to system II could be demonstrated for thyroxine and 3,3',5'-tri-iodothyronine also. System II had the properties of a carrier-mediated process.

Journal of Endocrinology (1989) 123, 143–148