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Changes in the amount of cytosolic 3,5,3'-tri-iodo-L-thyronine (T₃)-binding protein (CTBP) and its activator during administration of L-thyroxine (T₄) to thyroidectomized rats were investigated. Thyroidectomy decreased the amount of CTBP in the kidney, whereas the activator was not significantly modified by thyroidectomy. The activator was increased by administration of T₄ to thyroidectomized rats. The amount of CTBP was also increased by administration of T₄. The activator increased the maximal binding capacity (MBC) without changes in the affinity constant for T₃ binding in CTBP. A T₄-induced increase in MBC in cytosol inhibited nuclear T₃ binding in vitro by competition of T₃ binding between CTBP and the nuclear receptor.

These results suggest that thyroid hormone increases the capacity for cytosolic T₃ binding through increasing the amount of CTBP and its activator, and that these increases play a role in regulating the amount of T₃ that binds to its nuclear receptor.

Journal of Endocrinology (1989) 123, 99–104