HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Smith, K. B. Articles by Fraser, H. M. Search for Related Content PubMed Articles by Smith, K. B. Articles by Fraser, H. M.

We investigated the temporal relationship between serum concentrations of progesterone and immuno-reactive inhibin after treatment with an LHRH antagonist ([N-Ac-D-Nal(2)¹,D-pCl-Phe²,D-Trp³,D-hArg(Et₂)⁶,D-Ala¹⁰]-LHRH), during the mid-luteal phase in the macaque. Further, in an attempt to obtain a model of transitory suppression of luteal function, the effect of treatment with the LHRH antagonist for 1, 2 or 3 days during the mid-luteal phase on serum concentrations of progesterone and immunoreactive inhibin was compared. Differences in the pattern of decline of the two hormones were observed. Progesterone concentrations fell by 6 h after antagonist administration while inhibin was not significantly suppressed until 48 h. Treatment with three injections of LHRH antagonist caused a sustained suppression of luteal function as shown by low serum concentrations of progesterone and inhibin. Recovery of progesterone and inhibin secretion was observed in two out of six macaques treated with two injections of antagonist and in three out of six treated with a single injection. Therefore, with the regimens of LHRH antagonist which we employed this approach was not conducive to obtaining a reliable transitory suppression of luteal function. To elucidate further the gonadotrophin control of inhibin, six macaques were treated with three injections of the LHRH antagonist to induce a permanent suppression of luteal function but received concomitantly either human chorionic gonadotrophin (hCG) or human FSH daily for 5 days (n = 3 per group). FSH failed to prevent the antagonist-induced fall in progesterone and inhibin while hCG treatment completely reversed the inhibitory effects of the LHRH antagonist. These results give further support to the concept that the secretion of inhibin, like progesterone, is integrated with the LH control of the corpus luteum. The slower decline in inhibin after LHRH antagonist suggests that the gonadotrophic stimulus to the corpus luteum results in a more prolonged stimulus for inhibin than for progesterone secretion, or that inhibin has a longer metabolic clearance rate.

Journal of Endocrinology (1991) 128, 107–113

This article has been cited by other articles:

				A. Silvestri and H. M Fraser Oestrogen and progesterone receptors in the marmoset endometrium: changes during the ovulatory cycle, early pregnancy and after inhibition of vascular endothelial growth factor, GnRH or ovariectomy Reproduction, August 1, 2007; 134(2): 341 - 353. [Abstract] [Full Text] [PDF]

				J. A. McCracken, E. E. Custer, and J. C. Lamsa Luteolysis: A Neuroendocrine-Mediated Event Physiol Rev, April 1, 1999; 79(2): 263 - 323. [Abstract] [Full Text] [PDF]