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In-vitro autoradiography was used to demonstrate the regional distribution of ¹²⁵I-labelled insulin-binding sites in the liver, kidney and heart of normal rats and rats made diabetic with streptozotocin.

The distribution of insulin-binding sites in the liver of control rats was uniformly high, while in the kidney of control rats there was weak ¹²⁵I-labelled insulin binding in the medulla and dense binding in the cortex. In the hearts of control rats a high density of ¹²⁵I-labelled insulin-binding sites was evident both in the atrial and ventricular muscle.

Non-ketotic diabetes mellitus caused a marked increase in ¹²⁵I-labelled insulin-binding sites in both the liver and kidney with the former tissue exhibiting a time-dependent (7 to 62 days) increase. There was no apparent effect of diabetes on insulin-binding sites in the heart.

Since experimental diabetes causes (1) a decrease in circulating insulin concentration and (2) impaired insulin action at many target tissues, the increase in ¹²⁵I-labelled insulin-binding sites observed in the present study may represent a compensatory 'up regulation' of insulin receptors.

Journal of Endocrinology (1991) 128, 85–89