HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via Google Scholar Google Scholar Articles by Iguchi, T. Articles by Petrow, V. Search for Related Content PubMed PubMed Citation Articles by Iguchi, T. Articles by Petrow, V.

The role of 5-dihydrotestosterone (DHT) in the development of the genital organs and in the differentiation of the genital tract into prostate, coagulating gland (CG), bulbo-urethral gland (BUG) and seminal vesicle (SV) in male mice exposed prenatally to the 5-reductase inhibitor 6-methylene-4-pregnene-3,20-dione (6-MP) has been examined quantitatively. Female ICR mice were given 7 daily s.c. injections of the inhibitor (400 mg/day) starting on day 12 of gestation and the experiment was terminated on day 19 when the fetuses were removed by Caesarian section. In the prenatally 6-MP-exposed male mice the anogenital distance was significantly shorter than in the controls. Feminization of the nipples and hypospadias of the phallic urethra were noted. Development of prostate, CG and BUG was significantly suppressed. SV and testis development were not affected. These results lend further support to the conclusion that DHT is necessary for the development of the urogenital sinus (prostate, CG and BUG) and penis, and for the regression of the nipples in male mice. Reproductive abnormalities were not found in 90-day-old mice of both sexes exposed to 6-MP in utero. The 6-MP-exposed male and female mice had a normal reproductive capacity when mated with normal mice. These results show that 6-MP-induced growth retardation of reproductive organs is evident on day 19 of gestation, but that such retardation is no longer apparent in the adult.

Journal of Endocrinology (1991) 128, 395–401

This article has been cited by other articles:

				K. Ko, H. M. Theobald, R. W. Moore, and R. E. Peterson Evidence that Inhibited Prostatic Epithelial Bud Formation in 2,3,7,8-Tetrachlorodibenzo-p-dioxin-Exposed C57BL/6J Fetal Mice Is Not Due to Interruption of Androgen Signaling in the Urogenital Sinus Toxicol. Sci., June 1, 2004; 79(2): 360 - 369. [Abstract] [Full Text] [PDF]

				M. S. Mahendroo, K. M. Cala, D. L. Hess, and D. W. Russell Unexpected Virilization in Male Mice Lacking Steroid 5{alpha}-Reductase Enzymes Endocrinology, November 1, 2001; 142(11): 4652 - 4662. [Abstract] [Full Text] [PDF]

				S. Ohsako, Y. Miyabara, N. Nishimura, S. Kurosawa, M. Sakaue, R. Ishimura, M. Sato, K. Takeda, Y. Aoki, H. Sone, et al. Maternal Exposure to a Low Dose of 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD) Suppressed the Development of Reproductive Organs of Male Rats: Dose-Dependent Increase of mRNA Levels of 5{{alpha}}-Reductase Type 2 in Contrast to Decrease of Androgen Receptor in the Pubertal Ventral Prostate Toxicol. Sci., March 1, 2001; 60(1): 132 - 143. [Abstract] [Full Text] [PDF]

				B. A. Foster and G. R. Cunha Efficacy of Various Natural and Synthetic Androgens to Induce Ductal Branching Morphogenesis in the Developing Anterior Rat Prostate Endocrinology, January 1, 1999; 140(1): 318 - 328. [Abstract] [Full Text]