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An attempt has been made to compare the relative efficacy of two methods of medication with methyltestosterone, namely by absorption through the oral mucosa from slowly soluble tablets and by ingestion.

The method of comparison adopted was to estimate the extent to which menstruation was postponed after giving 25 mg methyltestosterone twice daily for 30 days from the onset of bleeding. The effectiveness of the two routes of administration was compared in the same individual.

The results indicate that buccal absorption is slightly more effective than ingestion.