HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by Oda, Y. Articles by Matsuzawa, Y. Search for Related Content PubMed Articles by Oda, Y. Articles by Matsuzawa, Y.

We examined the effect of noradrenaline on the release of 3,5,3'-tri-iodothyronine (T₃) and thyroxine (T₄) from perifused mouse thyroid. Noradrenaline suppressed the thyrotrophin (TSH)-stimulated release of T₃ and T₄. The addition of prazosin, which is a specific ₁ antagonist, or the depletion of Ca²⁺ from the perifusion buffer completely abolished the inhibitory effect of noradrenaline on TSH-stimulated T₃ and T₄ release. Noradrenaline did not inhibit TSH-stimulated cyclic adenosine 3',5'-monophosphate (cAMP) release in the presence of 3-isobutyl-1-methylxanthine (IBMX), which inhibits both cAMPspecific and calmodulin-sensitive phosphodiesterases. Noradrenaline significantly suppressed the TSH-stimulated release of T₃ and T₄ in the presence of IBMX. These results suggest that the inhibitory effect of noradrenaline on TSH-stimulated T₃ and T₄ release is not mediated through a cAMP-dependent process or the activation of a calmodulin-sensitive phosphodiesterase, and that this inhibition is mediated through a Ca²⁺-dependent process regulated by the ₁-adrenergic system in the mouse thyroid.

Journal of Endocrinology (1993) 138, 73–80