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A reduction in the uptake of ¹³¹I by the thyroid gland has been measured in inbred and F₁ hybrid mice reared in a hot environment (91 ± 1° F dry bulb, 85 ± 1° F wet bulb).

Rapid concentration of ¹³¹I occurs in the submaxillary glands following its intraperitoneal injection. Two and three-quarter hr after injection the submaxillary glands from heat-exposed mice had a higher ¹³¹I content than those from control counterparts. The inverse relationship between uptake of ¹³¹I by thyroid and salivary glands in heat-exposed and control mice is probably due to partition of the injected iodide between the tissues.

A significant decrease in the weight of the Harderian glands, allowing for small decreases in body weight, was found in the mice reared in the hot environment.