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The effect of thiouracil administration on the numbers of the follicular and stromal cells in the thyroid gland of the male albino rat was investigated. Both were found to increase in number, but a relatively greater increase occurred in the stromal cell population than in that of the follicular cells.

The mitotic rates for both types of cell were estimated. The maximum mitotic rates were seen in the group that had received 6 day's thiouracil treatment, after which there was a decline.

A difference between the effect of the fixatives, Carnoy and Zenker-acetic, on treated and nontreated thyroid glands was noted, more shrinkage occurring when treated glands were fixed in Zenker-acetic.

Tissue-culture experiments showed an increase in the numbers of both epithelial cells and fibroblasts migrated outwards from explants from stimulated glands.