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Journal of Endocrinology (1997) 155, S3-S6       DOI: 10.1677/joe.0.155S003
© 1997 Society for Endocrinology
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Journal of Endocrinology, Vol 155, Issue Suppl_1, S3-S6
Copyright © 1997 by Society for Endocrinology

Journal Article

Structure and function of somatostatin receptors in growth hormone control

I Shimon and S Melmed


This new generation of SRIF analogs offer exciting opportunities to improve hormone hypersecretion in patients with GH- and TSH-secreting pituitary adenomas and possibly even in patients harboring prolactinomas and non-functioning tumors. Future development of novel analogs with improved affinity for both SSTR2 and SSTR5 may have even greater potency to suppress pituitary hormone hypersecretion and block adenoma growth.


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L. Yang, S. C. Berk, S. P. Rohrer, R. T. Mosley, L. Guo, D. J. Underwood, B. H. Arison, E. T. Birzin, E. C. Hayes, S. W. Mitra, et al.
Synthesis and biological activities of potent peptidomimetics selective for somatostatin receptor subtype 2
PNAS, September 1, 1998; 95(18): 10836 - 10841.
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