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Journal of Endocrinology (1998) 156, 261-267       DOI: 10.1677/joe.0.1560261
© 1998 Society for Endocrinology
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Journal of Endocrinology, Vol 156, Issue 2, 261-267
Copyright © 1998 by Society for Endocrinology

Articles

Melatonin receptors in the human fetal kidney: 2-[125I]iodomelatonin binding sites correlated with expression of Mel1a and Mel1b receptor genes

JE Drew, LM Williams, LT Hannah, P Barrett, and DR Abramovich


Melatonin receptors in the human fetal kidney were identified and characterized by quantitative in vitro autoradiography using the melatonin agonist, 2-[125I]iodomelatonin. Specific binding was localized to cells in the nephrogenic region at the outer perimeter of the developing kidney and was time-dependent, saturable and inhibited in the presence of guanosine 5'-0-(3-thiotriphosphate) indicative of a G protein-coupled receptor. Expression of the Mel1a and Mel1b melatonin receptors in human fetal kidney was determined using RT-PCR. In situ hybridization confirmed the localization of the Mel1a mRNA transcripts. A role for melatonin in development of the human fetal kidney is postulated.


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