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DOI: 10.1677/joe.0.1730161
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Journal of Endocrinology, Vol 173, Issue 1, 161-167
Copyright © 2002 by Society for Endocrinology

Articles

Pit-1/GHF-1 and GH expression in the MCF-7 human breast adenocarcinoma cell line

C Gil-Puig, M Blanco, T Garcia-Caballero, C Segura, and R Perez-Fernandez


GH expression in mammary tumors has been related to the increase and spreading of cell proliferation. Using the MCF-7 human breast adenocarcinoma cell line, it has been demonstrated that autocrine GH-stimulated mammary carcinoma cell proliferation decreased the apoptosis rate and enhanced cell spreading. Surprisingly, no data are available about the presence of Pit-1 (the main pituitary regulator of GH) or GH expression in this cell line. Using RT-PCR, Western blot and immunohistochemistry, we have demonstrated the presence of both mRNA coding Pit-1 and GH as well as Pit-1 and GH protein in the MCF-7 cell line. These data could imply that Pit-1 may be an adequate target to inhibit breast cell proliferation.


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