HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Similar articles in ISI Web of Science Similar articles in PubMed Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via HighWire Citing Articles via ISI Web of Science (3) Citing Articles via Google Scholar Google Scholar Articles by Melcher, C. Articles by Pankratz, M. J Search for Related Content PubMed PubMed Citation Articles by Melcher, C. Articles by Pankratz, M. J

Institute for Genetics, Forschungszentrum Karlsruhe, Karlsruhe, Germany

(Requests for offprints should be addressed to M J Pankratz; Email: michael.pankratz{at}itg.fzk.de)

(C Melcher is now at Department of Neurobiology, Harvard Medical School, Boston, Massachusetts, USA)

Feeding can be regulated by a variety of external sensory stimuli such as olfaction and gustation, as well as by systemic internal signals of feeding status and metabolic needs. Faced with a major health epidemic in eating-related conditions, such as obesity and diabetes, there is an ever increasing need to dissect and understand the complex regulatory network underlying the multiple aspects of feeding behavior. In this minireview, we highlight the use of Drosophila in studying the neural circuits that control the feeding behavior in response to external and internal signals. In particular, we outline the work on the neuroanatomical and functional characterization of the newly identified hugin neuronal circuit. We focus on the pivotal role of the central nervous system in integrating external and internal feeding-relevant information, thus enabling the organism to make one of the most basic decisions – to eat or not to eat.

This article has been cited by other articles:

				A. Kohyama-Koganeya, Y.-J. Kim, M. Miura, and Y. Hirabayashi A Drosophila orphan G protein-coupled receptor BOSS functions as a glucose-responding receptor: Loss of boss causes abnormal energy metabolism PNAS, October 7, 2008; 105(40): 15328 - 15333. [Abstract] [Full Text] [PDF]

				D. D. Kaplan, G. Zimmermann, K. Suyama, T. Meyer, and M. P. Scott A nucleostemin family GTPase, NS3, acts in serotonergic neurons to regulate insulin signaling and control body size Genes & Dev., July 15, 2008; 22(14): 1877 - 1893. [Abstract] [Full Text] [PDF]

				M. J. Krashes and S. Waddell Rapid Consolidation to a radish and Protein Synthesis-Dependent Long-Term Memory after Single-Session Appetitive Olfactory Conditioning in Drosophila J. Neurosci., March 19, 2008; 28(12): 3103 - 3113. [Abstract] [Full Text] [PDF]