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The placenta and the foetal membranes of rats (pregnant 5–21 days) have been assayed by histochemical methods for 3β-hydroxysteroid dehydrogenase (3β-HSDH), NAD-dependent, and 17- and 17β-hydroxysteroid dehydrogenases (17- and 17β-HSDH), both NAD and NADP-dependent.

3β-HSDH was limited to the trophoblastic giant cells of the first generation, whereas 17- and 17β-HSDH were present in both the first- and second-generation giant cells and also in the endodermal cells of the inverted yolk sac placenta.

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				M. V. J. Mustonen, V. V. Isomaa, T. Vaskivuo, J. Tapanainen, M. H. Poutanen, F. Stenbäck, R. K. Vihko, and P. T. Vihko Human 17{beta}-Hydroxysteroid Dehydrogenase Type 2 Messenger Ribonucleic Acid Expression and Localization in Term Placenta and in Endometrium during the Menstrual Cycle J. Clin. Endocrinol. Metab., April 1, 1998; 83(4): 1319 - 1324. [Abstract] [Full Text]