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In a preliminary study designed to examine the nature of experimentally induced changes in thyroid-pituitary relationships the relative concentrations of radioactive iodide in the goitrogen-blocked thyroid gland and serum (T:S ratio) of normal rats diverged so widely from those reported in the literature (e.g. Vanderlaan & Vanderlaan, 1947; Halmi, 1957) as to suggest the presence of some uncontrolled factor. The possible influence of physical environment, diet and strain of rat, was considered and in the experiment to be described the first of these was standardized, the others providing two variables which were studied in relation to their main effects and interactions.

Six female rats of comparable weight (239 ± 6 g.) from each of five different sources (the term 'strain' is subsequently used for convenience) were assembled and housed at 21 ± 0·5° in ten identical cages each containing three rats from the same strain and on the same diet.