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Journal of Endocrinology (1966) 35, 13-17    DOI: 10.1677/joe.0.0350013
© 1966 Society for Endocrinology
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CORTISOL METABOLISM BY THE ISOLATED AND PERFUSED NEWBORN RABBIT LIVER

 F. SERENI, E. CASTEGNARO, L. PERLETTI and G. SALA

After perfusion of newborn rabbit liver with [1,2-3H]cortisol two radioactive metabolites were isolated from the perfusate and identified as 3{alpha},11β,17{alpha},21-tetrahydroxy-5β-pregnan-20-one (THF) and 11β,17{alpha},20β,21-tetrahydroxypregn-4-en-3-one (20β-dihydrocortisol). The amount of metabolites recovered in the perfusate of livers of 1-day-old animals was lower than when 11- to 12-day-old animals were used. The results suggest a relative deficiency in the liver of newborn rabbits of the enzyme reducing ring A and the 20-oxo group of cortisol.






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Copyright © 1966 by the Society for Endocrinology.