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After the oral administration of tritiated 3β,21-dihydroxypregn-5-en-20-one (21-hydroxypregnenolone) to a normal subject, 40% of the radioactivity was excreted during the first 24 hr. The disulphate fraction which contained mainly 21-hydroxypregnenolone 3,21-disulphate, accounted for 62 % of the total radioactivity. The monosulphate fraction accounted for 6·8% of the total radioactivity. In the glucosiduronic acid fraction (8·7%) 21-hydroxypregnenolone, tetrahydrodeoxycorticosterone and allotetrahydrodeoxycorticosterone were detected.

After the simultaneous oral and intravenous administration of inert and tritiated 3β,17,21-trihydroxypregn-5-en-20-one (17,21-dihydroxypregnenolone) only 25·7% of the radioactivity was excreted in the first 24 hr. The monosulphate fraction, accounting for 64% of the total radioactivity, contained 3β,17,20,21-tetrahydroxypregn-5-en-20-one, dehydroepiandrosterone and 17,21-dihydroxypregnenolone. In the glucosiduronic acid fraction (15%), 17β,21-dihydroxypregnenolone, tetrahydro-11-deoxycortisol, allotetrahydro-11-deoxycortisol, aetiocholanolone and androsterone were detected.