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Journal of Endocrinology (1966) 35, 255-NP    DOI: 10.1677/joe.0.0350255
© 1966 Society for Endocrinology

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HYDROXYSTEROID DEHYDROGENASE ACTIVITY IN NORMAL HUMAN PLACENTA FROM SIX WEEKS TO FORTY-TWO WEEKS OF GESTATION

D. McK. HART

Fifty-two normal human placentae from the 6th to the 42nd week of pregnancy were surveyed for 3{alpha}-, 3β-, 6β-, 11{alpha}-, 11β-, 12{alpha}-, 16{alpha}-, 16β-, 17{alpha}-, 17β-, 20β-, 21- and 24-hydroxysteroid dehydrogenase (HSD) activities.

Strong NAD-linked 3β-, 16β-, and 17β-HSD activities and moderate NADP-linked 3β-, 16β- and 17β-HSD activities were found in the villous trophoblast at all ages. Weak 3{alpha}- and weak or trace 6β- and 11β-HSD activities were found in the trophoblast of some placentae using NAD as cofactor, with no obvious age distribution. Moderate 17β-HSD activity, NAD-linked only, was found in the villous stroma and vasculature.







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