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The distribution of neurophysin in subcellular fractions obtained by differential centrifugation of bovine neurohypophyses is essentially similar to the distribution of the hormones. The neurosecretory particle fraction contained more neurophysin than other fractions and neurophysin comprised half of its water soluble protein. Estimates were derived for the concentrations of oxytocin, vasopressin and neurophysin in neurosecretory granules.

In experiments in which neurosecretory granules were suspended in media at pH values between 6·2 and 8·0 it was found that release of hormones increased with increasing pH.

The role of neurophysin in the transport and release of neurohypophysial hormones is discussed.