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The effect was studied of a single large dose of a glucocorticoid administered to rats at an age when they did not respond to stress (Schapiro, Geller & Eiduson, 1962) and when the feed-back control of the hypophysio-adrenocortical system was still undeveloped.

Within the first 24 hr. of life, one group of Wistar strain rats, with a mean weight of 5·4 g., received an s.c. injection of 250 µg. dexamethasone (16-methyl-9-fluoro-¹cortisol) sodium phosphate. Two other groups served as controls. One consisted of animals born on the same day as the treated rats, the other group were rats which had reached the same weight as the experimental animals when the latter were killed.

On the fourth day after injection, the experimental animals began to show signs of impaired growth and developed an appearance similar to that seen in experimentally induced wasting syndromes (Miller, 1962; Schlesinger & Mark, 1964; Fachet,