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It has been shown previously (Jellinck & Lucieer, 1965) that liver microsomes derived from male rats convert a higher proportion of [¹⁴C]oestradiol to its 2-hydroxy derivative and to water-soluble products than similar preparations from female rats. This sex difference in oestrogen metabolism could be altered by changing the hormonal environment; male rats acquired a female metabolic pattern when implanted with a pellet of oestrone (Jellinck & Woo, 1967). A number of natural and synthetic oestrogens in pellet form were therefore tested to determine whether they had the same action as oestrone on rat liver microsomes. The effect of structurally related non-oestrogenic analogues was also examined.

Compounds to be tested were compressed into cylindrical pellets (15–25 mg.) and implanted into adult male hooded or Sprague-Dawley rats. The dose released from the pellets is very small (e.g. < 50 µg. oestrone or stilboestrol/day, Jellinck & Woo, 1967). The animals were killed