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CONTENTS: Introduction

Biological inactivation and metabolism of oestrogens in the normal liver of animals

Biological inactivation and metabolism of oestrogens in the damaged liver of animals

Biological inactivation and metabolism of oestrogens in the normal human liver

The role of conjugation of oestrogens in their biological inactivation

Role of the enterohepatic circulation in the biological inactivation and metabolism of oestrogens in human subjects

Oestrogen metabolism in human subjects with liver disease

Studies in vitro

Studies on urinary excretion of oestrogens using biological and chemical methods

Studies on the biological effects of oestrogens on the vaginal smear and urinary sediment in liver disease

Studies on the mechanism leading to increased oestrogen excretion and to symptoms of increased oestrogen activity in the organism

The relation of the disturbed metabolism of oestrogens to the clinical symptoms seen in liver disease

Conclusions

References

INTRODUCTION: The nature of the changes in oestrogen metabolism in liver