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Journal of Endocrinology (1970) 46, 93-99    DOI: 10.1677/joe.0.0460093
© 1970 Society for Endocrinology

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THYROID FUNCTION IN PROTEIN-DEPLETED RATS

W. H. FLORSHEIM, BIRUTA Z. SUHR, R. T. MIRISE and A. D. WILLIAMS

Renal iodide clearance in rats was reduced rapidly when the animals were fed a protein-depletion diet. If the iodine content of the protein-depletion diet is high, this results in an increase in the serum iodide levels to concentrations in excess of 150 µg./100 ml. Protein-bound iodine was elevated due to the accumulation of iodinated serum albumin. Thyroid hormonal iodoamino acid content was transiently depressed, presumably by the mechanism described by Wolff & Chaikoff (1948). Thyroxine metabolism was not affected except for a change in the partition of thyroxine between liver and serum. There was no evidence for pituitary involvement in the effects of protein depletion on thyroid function.







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