HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by SCHNEIDER, H. P. G. Articles by McCANN, S. M. Search for Related Content PubMed Articles by SCHNEIDER, H. P. G. Articles by McCANN, S. M.

Dopamine-containing neurons with cell bodies in the arcuate nucleus and axons projecting to the median eminence have been discovered (Fuxe & Hökfelt, 1967) and dopamine (DA) has been shown to evoke discharge of both luteinizing hormonereleasing factor (LRF) (Schneider & McCann, 1969a) and follicle-stimulating hormone-releasing factor (Kamberi, Schneider & McCann, 1969) from hypothalamic fragments incubated in vitro. Injection of DA into the third ventricle (3rd V) of rats increased plasma luteinizing hormone (LH) (Schneider & McCann, 1969b). The present experiments were performed to determine if stimulation of LH release in vivo was brought about by release of LRF.

Hypophysectomized rats were used since LRF has been detected in peripheral blood of hypophysectomized but not intact rats (Nallar & McCann, 1965). Stainless steel cannulae (22 gauge) were implanted into the 3rd V of hypophysectomized adult female Sprague—Dawley rats (Hormone Assay Lab., Chicago). One week or more after implantation of