HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by MAZAHERI, A. Articles by CHAPMAN, J. R. Search for Related Content PubMed Articles by MAZAHERI, A. Articles by CHAPMAN, J. R.

Kamyab, Fotherby & Klopper (1968) showed that there were similarities between the in-vivo metabolism in man of ¹⁴C-labelled norethisterone (17-ethynyl-19-nortestosterone) and lynestrenol (3-deoxynorethisterone) and suggested that some of these similarities might be due to the conversion of the latter to the former. The present communication describes such a conversion in vitro.

Rabbit liver was homogenized and incubated by the procedure described by Davidson & Fotherby (1965) except that: (1) each flask contained in addition 0·0012 M-NADPH, (2) the incubations proceeded for 16 hr., (3) ethyl acetate was used for extraction instead of benzene and (4) the residue obtained, following evaporation of the ethyl acetate, was submitted to a hexane-methanol partition (Fotherby, Colas, Atherden & Marrian, 1957). For the large-scale incubations, 20 mg. steroid in 0·2 ml. ethanol were added to an homogenate of 20 g. liver. Thin-layer chromatography was carried out using either silica gel G (Merck and