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Transmucosal electrical potential difference (p.d.), short-circuit current, electrical resistance and Na⁺ influx rate of the descending colon were similar in euthyroid and hypothyroid rats, the latter having been treated earlier with an ablation dose of ¹³¹I. However, in contrast to the considerable p.d. increase found in normal rats, little change of p.d. was found in hypothyroid rats when they were Na⁺ depleted or given an intravenous aldosterone infusion. A single small dose of tri-iodothyronine (T₃) (1 µg/100g body weight) or a larger dose of thyroxine given to hypothyroid rats 10–16 h before aldosterone, restored the p.d. response to normal, although these doses did not influence the animal's oxygen consumption. Fasting for 3 days or giving actinomycin D (8 µg/100 g body weight) abolished the effect of T₃ but this did not influence the action of aldosterone in euthyroid animals.