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We have been studying the endocrine system of elderly men with prostatic disorders, none of whom had any clinical or routine laboratory evidence of an endocrine disorder. The presence of prostate disease, so common in males over 60, may be an incidental finding, since we do not have data in age-matched controls. In 8 patients studied to date, 4 with prostate carcinoma and 4 with benign prostatic hypertrophy, decreased or absent pituitary luteinizing hormone (LH) reserve has been uniformly noted. No other abnormalities of pituitary function have been noted except that two patients had increased 24-h urinary total pituitary gonadotrophins, probably indicating primary testicular failure. Investigations included studies of growth hormone (GH) reserve by measurement of plasma GH levels following arginine stimulation (Merimee & Rabinowitz, 1969). Although 4 patients had Stage IV carcinoma of the prostate, none was cachectic and body weight in this group ranged from 2·5 to 16