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Since there are in-vivo effects of growth hormone (GH) on cartilage and adipose tissue which cannot be duplicated in vitro (Salmon & Daughaday, 1957; Daughaday & Reeder, 1966; Goodman, 1968) it has been postulated that pituitary GH is modified in the body before exerting its peripheral action.

In sheep, labelled GH is altered by the kidneys and returned to the circulation in an immunologically modified form (Wallace, Stacy & Thorburn, 1969). The altered material may still be biologically active and responsible for some of the observed effects of pituitary GH. We used the fat mobilizing action of GH in sheep (Bassett & Wallace, 1966) to test whether nephrectomy had an effect on the biological activity of injected GH.

The sheep were fasted for 24 h before the start of all experiments and throughout the experimental period. Blood samples were collected into heparinized tubes from jugular cannulae inserted the day before