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The capacity of specific antisera against growth hormone (GH) to inhibit the biological activity of this hormone has been previously described. Most experiments were carried out on hypophysectomized rats, and the biological activity of GH in the tibia assay could be neutralized by its specific antiserum or crossreacting antisera (Hayashida & Contopoulos, 1967), or by anti-pituitary serum (Anigstein, Rennels & Anigstein, 1960). Pierpaoli & Sorkin (1967, 1968) observed considerable impairment of body growth, often manifested as a runting syndrome, and extensive degeneration of lymphoid tissues after administration of antisera to pituitary extracts of bovine GH to young mice.

The purpose of this study was to investigate the effect of specific antibodies to rat GH (RGH) on young rats. Special attention was paid to the morphology and function of the lymphoid system. Because the thymus plays an important role in development of the lymphoid system early in life, newborn rats were