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Urinary oestrogens, pregnanediol and the 6-oxygenated metabolites of progesterone increase during normal pregnancy (Fotherby, James, Kamyab, Klopper & Wilson, 1965). This report describes the excretion of the 6-oxygenated metabolites of progesterone, pregnanediol, oestrone, oestradiol and oestriol during phases of pregnancy where the normal processes regulating steroidogenesis were disturbed.

Urinary steroids were estimated by the following methods: oestriol, Klopper & Wilson (1962); oestrone and oestradiol, Brown (1955) slightly modified by Shearman (1964); pregnanediol, Klopper, Michie & Brown (1955); 6-oxygenated progesterone metabolites, James & Fotherby (1965).

Corticotrophin (ACTH) 50 u., in 540 ml 0·9% NaCl soin was administered i.v. to the mother over 8 h during a 12-h urine collection period. Dehydroepiandrosterone sulphate (DHAS) sodium salt (500 mg) was similarly administered. The subjects were volunteers and resided as hospital in-patients. Mrs A. was clinically normal (gestation 29–30 weeks) and received a DHAS infusion on 27/vi. Mrs B. (33–37 weeks gestation) was carrying