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Chlorpropamide has been introduced into clinical practice as a treatment for diabetes insipidus (Arduino, Ferraz & Rodrigues, 1966) but its mode of action is unclear. The effect of chlorpropamide, its two principle breakdown products and two other sulphonylurea drugs has been studied both alone and in combination with vasopressin and dibutyryl cyclic AMP on water transport across the bladder wall of the marine toad, Bufo marinus (Bentley, 1958). A hemi-bladder from each toad acted as control to that used experimentally (sides A and B in Table 1) and the internal bladder solution was 10 mM-choline chloride.

When added to various concentrations of vasopressin in Ringer's solution on the serosal surface of the bladder, chlorpropamide (3·6 x 10^–4 mol/l) caused a significant increase in water transport across the bladder wall. However, the drug alone had no effect (expt A). Chlorpropamide did not significantly increase water transport after the addition of