HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by HYNIE, S. Articles by SHARP, G. W. G. Search for Related Content PubMed Articles by HYNIE, S. Articles by SHARP, G. W. G.

In view of the report that Mn²⁺ stimulates sodium transport in the toad bladder but inhibits the effect of vasopressin on both water flow and sodium transport, the effects of this ion on adenyl cyclase from mucosal epithelial cells of toad bladder were investigated. Mn²⁺ was found to inhibit activation of adenyl cyclase by arginine vasopressin in the presence of Mg²⁺ and had no effect on activation of the enzyme by sodium fluoride. This is in marked contrast to the effects of Mn²⁺ on hormonal activation of adenyl cyclase from other tissues in which no inhibitory effects are seen and in which Mn²⁺ can replace Mg²⁺ in the reaction mixture. It is concluded that stimulation of sodium transport by Mn²⁺ is unlikely to be explainable by adenyl cyclase activation and that Mn²⁺ is not useful in the differentiation of the two forms of adenyl cyclase which are thought to be required for mediation of water flow and sodium transport stimulation by vasopressin.