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A. LEBODZISKI

The highest level of serum free thyroxine (T₄) on the first day of life occurs in the pig (lebodziski, 1965) and the human infant (Marks, 1965). It decreases thereafter as the result of a gradual rise in the thyroxine-binding globulin (TBG) in pigs, or in the thyroxine-binding pre-albumin fraction in infants (Van den Schrieck, 1969). An increase in the half-life of T₄ in blood with a simultaneous rise in TBG in newborn calves has also been reported (Nathanielsz, 1969). Because of the physiological change in the thyroxine-binding protein, the plasma T₄ level does not seem to be an adequate indicator of the peripheral utilization of the hormone in the neonatal period. In the present experiment the tri-iodothyronine-binding coefficient (T₃-BC), regarded as proportional to free T₄ (Gimlette, 1967), was used for assessment of variation in levels of the metabolically active form of the hormone in