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Experiments were carried out to determine whether alloxan diabetes in rats altered: (1) the level of plasma seromucoid (a small carbohydrate-rich fraction), (2) the perchloric acid (PCA)-insoluble protein, making up the remainder of the plasma protein, and (3) the ability of the animal to incorporate [¹⁴C]glucosamine and [¹⁴C]leucine into these plasma fractions.

Diabetes was produced in 20 male Wistar rats (250–275 g) by the following procedure. Rats, fasted for 16 h, were lightly anaesthetized with ether and injected i.v. with alloxan (70 mg/kg) in 0·9% NaCl solution acidified to pH 3·5. They were then given protamine zinc insulin s.c. at a daily dose of 2 u. for 7 days, 1 u. for 5 days and 0·5 u. for 5 days. Experiments were carried out 3 days after the last dose of insulin. In the 24 h preceding the experiments, urinary output of glucose per rat was 667 ±