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Bryant, Connan & Greenwood (1968), using a radioimmunoassay technique to measure plasma levels of prolactin in sheep, investigated the hypothesis that certain drugs, including phenothiazine derivatives, stimulate the secretion of prolactin from the anterior pituitary gland (Ben-David, Dikstein & Sulman, 1965). They noticed that there was a rise in the level of plasma prolactin in sheep within 1 h of injection of acepromazine. Saji (1966), however, using a haemagglutination inhibition procedure to investigate the long-term effect of perphenazine on blood prolactin levels in the ewe, demonstrated a rise in hormone level for a period of 15 days after treatment. Haemagglutination procedures have been criticized on the grounds of specificity due to interference by materials such as serum proteins present in the system (Read, Eash & Najjah, 1962), and it is the purpose of this communication to report an investigation of the observations of Saji (1966) using a solid-phase radioimmunoassay system