HOME HELP CONTACT US SUBSCRIPTIONS ARCHIVE SEARCH TABLE OF CONTENTS		QUICK SEARCH:   [advanced] Author: Keyword(s): Year:  Vol:  Page:

This Article Full Text (PDF) Alert me when this article is cited Alert me if a correction is posted Services Similar articles in this journal Alert me to new issues of the journal Download to citation manager Citing Articles Citing Articles via Google Scholar Google Scholar Articles by LANGER, P. Search for Related Content PubMed Articles by LANGER, P.

In rats to which ¹²⁵I was administered for 28 days, the level of protein-bound ¹²⁵I (PB¹²⁵I) (estimated by trichloroacetic acid precipitation or filtration on a Sephadex G-25 column) was measured. In intact animals, after a single dose of 16 mg thiocyanate ion, a significant decrease of PB¹²⁵I was found, which was inversely related to the level of thiocyanate in plasma. The decrease was much faster than that in rats after thyroidectomy. From these findings an extrathyroidal effect of thiocyanate was postulated and tested in rats fed ¹²⁵I^– for 28 days and then thyroidectomized immediately before the administration of a single dose of 16 mg thiocyanate ion or 15 mg propylthiouracil. The level of PB¹²⁵I in most of the latter animals 4, 8, 18 and 24 h after the administration of the drugs was significantly lower than that in thyroidectomized controls.