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Treatment of insulin with iodine or formaldehyde eliminates its hypoglycaemic effect but does not affect the antilipolytic properties of insulin. Pharmacological doses of iodinated insulin injected into rabbits inhibit the lipolysis caused by human growth hormone, corticotrophin, lipotrophin or fasting.

Iodinated or formaldehyde-treated insulin was found to increase the hypoglycaemic effect of exogenous native insulin. This action may be accounted for by the antilipolytic activity of these insulin derivatives. Iodinated insulin could also be shown to decrease the glycaemia after a glucose load.

The significance of increased lipolysis in the pathogenesis of a large group of pathological conditions caused by increased resistance of the hypothalamus to homeostatic inhibition is discussed.