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Removal of the pituitary gland from the rat produces a decrease in the rate of sebum secretion (Nikkari & Valavaara, 1969; Ebling, Ebling & Skinner, 1969; Thody & Shuster, 1970 a). However, it is not established which pituitary hormones are involved in the control of sebaceous gland activity. In this study we have examined the effect of a new pituitary hormone, β-lipotrophin (β-LPH) (Birk, & Li, 1964; Li, 1968), on the rate of sebum secretion in the rat.

Female Wistar rats were ovariectomized when 5–6 weeks old and hypophysectomized at 7–8 weeks of age. Two weeks later the rats were divided into two groups and received either no hormone treatment (controls) or 0·1 mg β-LPH/day. The injections were given subcutaneously and continued for 2 weeks. At the end of this time the rate of sebum secretion was measured by the method of Archibald & Shuster (1970).

In this method the