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Several authors have proposed histamine as the mediator of oestrogen action (Holden, 1939; Spaziani & Szego, 1958), and the uterine release of histamine during early pregnancy has also been considered an oestrogenic effect (Shelesnyak, 1960), though later work proved this to be unlikely (Marcus & Shelesnyak, 1967). We have studied the influence of histamine on the uptake of oestradiol-17β by its target organs.

Adult female Wistar rats, ovariectomized 2 weeks previously, were injected s.c. with 5·76 x 10⁶ d.p.m. of [6,7-³H]oestradiol-17β in 0·5 ml 0·9% NaCl solution. Oestradiol-17β (Nuclear Chicago Inc., sp. act. 40 Ci/mM) was previously purified by paper chromatography in benzene—formamide (Neher, 1964). Immediately after injection of the steroid, the experimental group received 50 mg histamine dihydrochloride s.c. in 0·5 ml 0·9% NaCl solution while control animals received only the vehicle.

The animals were killed 75 min later by cervical dislocation, and radioactivity was