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A decrease in the flow of bile and other digestive secretions may follow injections of antidiuretic hormone (ADH) at least in rats and dogs (Homsher & Cotzias, 1965; Wakim, 1967). In sheep, this hormone is released into the circulation after feeding (Stacy & Brook, 1965), but no information is available concerning the effect of this ADH on the entry of bile and other secretions into the sheep intestine. In these experiments, arginine vasopressin (Pitressin, Parke Davis Company, Sydney) was infused into the jugular vein of sheep with biliary fistulae (Heath, Caple & Redding, 1970).

To establish constant basal rates of bile formation in all the experiments, the sheep received infusions of either secretin (0·92 u./min; Karolinska Institutet, Stockholm) or taurocholate (43 µmol/min; Sigma Chemical Co., St Louis, Missouri), both important normal stimulants of bile formation in sheep (Heath, 1970; Heath et al. 1970). In the first series of experiments, low doses